详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Th17/Treg balance is regulated by myeloid-derived suppressor cells in experimental autoimmune myocarditis

98| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

单位： [1]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [3]Department of Emergency, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [4]Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [5]Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出处：

DOI：

ISSN：

关键词： autoimmune myocarditis in experiment balance inflammation myeloid‐derived suppressor cells Th17 cells Treg

摘要：

Autoimmune myocarditis is caused by both innate and adaptive immune responses. Many studies have found that myeloid-derived suppressor cells (MDSCs) suppress T-cell responses and reduce immune tolerance, while MDSCs may serve as a key player in inflammatory responses and pathogenesis in variety of autoimmune diseases. However, research into the role of MDSCs in experimental autoimmune myocarditis (EAM) remains lacking.We discovered that the expansion of MDSCs in EAM was closely related to the severity of myocardial inflammation. At an early stage of EAM, both adoptive transfer (AT) and selective depletion of MDSCs could inhibit the expression of IL-17 in CD4+ cells and downregulate the Th17/Treg ratio, alleviating excessive inflammation of EAM myocarditis. In another experiment, in addition, MDSCs transferred after selective depletion could increase IL-17 and Foxp3 expressions in CD4+ cells, as well as the Th17/Treg ratio, contributing to the aggravation of myocardial inflammation. MDSCs promoted the Th17 cell induction under Th17-polarizing conditions in vitro but suppressed Treg expansion.These findings suggest that MDSCs play a plastic role in sustaining mild inflammation in EAM by shifting Th17/Treg balance.© 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 4 区医学

小类 | 4 区免疫学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区免疫学

JCR分区：

出版当年[2021]版：

Q4 IMMUNOLOGY

最新[2023]版：

Q3 IMMUNOLOGY

影响因子： 3.1 最新[2023版] 2.9 最新五年平均 2.493 出版当年[2021版] 2.602 出版当年五年平均 2.239 出版前一年[2020版] 3.2 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

共同第一作者：

通讯作者：

通讯机构： [4]Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. [5]Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [*1]Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. [*2]Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Cardioprotective Role of Myeloid-Derived Suppressor Cells in Heart Failure [2]Circulating myeloid-derived suppressor cells in patients with pancreatic cancer [3]Diverse functions of myeloid-derived suppressor cells in autoimmune diseases [4]Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy [5]The interaction of tumor cells and myeloid-derived suppressor cells in chronic myelogenous leukemia [6]Myeloid-derived Suppressor Cells Activate Liver Natural Killer Cells in a Murine Model in Uveal Melanoma [7]Intrauterine administration of peripheral blood mononuclear cells (PBMCs) improves embryo implantation in mice by regulating local Treg/Th17 cell balance [8]Splenectomy suppresses growth and metastasis of hepatocellular carcinoma through decreasing myeloid-derived suppressor cells in vivo [9]Targeting Ornithine Decarboxylase by α-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells [10]髓源性抑制细胞——血液肿瘤的免疫治疗靶点