详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Cystathionine-γ-lyase attenuates inflammatory response and pain of osteoarthritis

166| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

单位： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095,Jiefang Ave,Wuhan,Hubei,430030,China. [2]Department of Obstetrics and Gynecology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, 100, Xianggang Road, Wuhan 430000, China.

出处：

DOI：

ISSN：

关键词： Osteoarthritis Cystathionine-γ-Lyase Pain Inflammation NF-κB

摘要：

The chronic articular disease osteoarthritis (OA) is characterized by osteophyte generation, subchondral bone remodeling, and cartilage deterioration. Low levels of H2S catalyzed by cystathionine-γ-lyase (CSE) encoded by Cthhas neuroprotective, cardioprotective, anti-apoptotic, and anti-inflammatory effects thus, Cth is being developed as a potential therapy for the management of the pathogenesis and symptoms of osteoarthritis. Single-cell RNA sequencing (scRNA-seq) and immunohistochemistry of human cartilage revealed that the expression of CTH was decreased in OA patients. We found that Cthoverexpression decrease IL-1β-induced overactivation of the NF-κB signaling pathway. In vivo, Cthoverexpression relieved pain response and cartilage damage in the anterior cruciate ligament transection (ACLT) rat model. In vitro, CSE alleviated chondrocytes catabolism, inflammation, apoptosis, and senescence, and suppressed the NF-κB pathway. We postulate that CSE has therapeutic effects in suppressing inflammation and degeneration in OA and should be further investigated clinically.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区免疫学 2 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药学 3 区免疫学

JCR分区：

出版当年[2021]版：

Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

最新[2024]版：

Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 4.7 最新[2024版] 5 最新五年平均 5.714 出版当年[2021版] 5.597 出版当年五年平均 4.932 出版前一年[2020版] 5.6 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095,Jiefang Ave,Wuhan,Hubei,430030,China.

通讯作者：

通讯机构： [1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095,Jiefang Ave,Wuhan,Hubei,430030,China. [*1]Department of Orthopedics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095,Jiefang Ave,Wuhan,Hubei,430030,China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin [2]Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis [3]An alkaloid from Menispermum dauricum, dauricine mediates Ca2+ influx and inhibits NF-κB pathway to protect chondrocytes from IL-1β-induced inflammation and catabolism [4]Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin [5]Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways [6]Protective effects of Erdosteine on interleukin-1β-stimulated inflammation via inhibiting the activation of MAPK, NF-κB, and Wnt/β-catenin signaling pathways in rat osteoarthritis [7]Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes [8]PM2.5 aggravates airway inflammation in asthmatic mice: activating NF-κB via MyD88 signaling pathway [9]Histological Features of Uterine Myometrial Dysfunction: Possible Involvement of Localized Inflammation [10]Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-ΚB pathways