Enantioselective labeling of important bioactive molecules in complex biological environments by artificial receptors has drawn great interest. From both the slight difference of enantiomers' physicochemical properties and inherently complexity in living organism point of view, it is still a contemporary challenge for preparing practical chiral device that could be employed in the model animal due to diverse biological interference. Herein, we introduce ?-cyclodextrin onto graphene oxide for fabricating ?-cyclodextrin and graphene oxide assemblies, which provided an efficient nanoplatform for chiral labelling of D-phenylalanine with higher chiral discrimination ratio of K-D/K-L = 8.21. Significantly, the chiral fluorescence quenching effect of this ?-CD-GO nanoplatform for D-phenylalanine enantiomer in zebrafish was 7.0-fold higher than L-isomer, which exhibiting real promise for producing practical enantio-differentiating graphene-based systems in a complex biological sample.
基金：
National Natural Science Foundation of China [22006055]; State Key Laboratory of Environmental Chemistry and Ecotoxicology, RCEES, CAS [KF2017-14]; Central Government Guides Local Scientific and Technological Development Special Fund Project of Hubei Province [2022BGE260]
第一作者单位：[1]Jianghan Univ, Sch Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent T, Wuhan 430056, Peoples R China
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推荐引用方式(GB/T 7714)：
He Yuqing,Ye Ziqi,Zhu Fei,et al.Enantioselective Labeling of Zebrafish for D-Phenylalanine Based on Graphene-Based Nanoplatform[J].MOLECULES.2023,28(9):doi:10.3390/molecules28093700.
APA：
He, Yuqing,Ye, Ziqi,Zhu, Fei,Qiu, Tianxiang,Dai, Xiyan...&Mao, Xiaowei.(2023).Enantioselective Labeling of Zebrafish for D-Phenylalanine Based on Graphene-Based Nanoplatform.MOLECULES,28,(9)
MLA：
He, Yuqing,et al."Enantioselective Labeling of Zebrafish for D-Phenylalanine Based on Graphene-Based Nanoplatform".MOLECULES 28..9(2023)
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