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The effect of silicon groups on the physicochemical property and bioactivity of L-phenylalanine derived poly(amide-imide)

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单位： [1]Shenzhen Research Institute of Wuhan University of Technology, Shenzhen, China. [2]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, China. [3]Department of Orthopedic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.

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关键词： biocomposite chemical properties compression molding polymer-matrix composites

摘要：

Poly(amide-imide) (PAI), serving as a synthetic polymer, has been widely used in industry for excellent mechanical properties, chemical resistance and high thermal stability. However, lack of suitable cell niche and biological activity limited the further application of PAI in biomedical engineering. Herein, silicon modified L-phenylalanine derived poly(amide-imide) (PAIS) was synthesized by introducing silica to L-phenylalanine derived PAI to improve physicochemical and biological performances. The influence of silicon amount on physicochemical, immune, and angiogenic performances of PAIS were systemically studied. The results show that PAIS exerts excellent hydrophilic, mechanical, biological activity. PAIS shows no effects on the number of macrophages, but can regulate macrophage polarization and angiogenesis in a dose-dependent manner. This study advanced our understanding of silicon modification in PAI can modulate cell responses via initiating silicon concentration regulation. The acquired knowledge will provide a new strategy to design and optimize biomedical PAI in the future.© 2023 Wiley Periodicals LLC.

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出版当年[2022]版：

大类 | 3 区工程技术

小类 | 4 区材料科学：生物材料 4 区工程：生物医学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区工程：生物医学 4 区材料科学：生物材料

JCR分区：

出版当年[2021]版：

Q3 ENGINEERING, BIOMEDICAL Q3 MATERIALS SCIENCE, BIOMATERIALS

最新[2023]版：

Q2 ENGINEERING, BIOMEDICAL Q3 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 3.2 最新[2023版] 3.1 最新五年平均 3.405 出版当年[2021版] 3.42 出版当年五年平均 3.368 出版前一年[2020版] 3.4 出版后一年[2022版]

第一作者：

第一作者单位： [1]Shenzhen Research Institute of Wuhan University of Technology, Shenzhen, China. [2]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, China.

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通讯作者：

通讯机构： [1]Shenzhen Research Institute of Wuhan University of Technology, Shenzhen, China. [2]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, China. [*1]Shenzhen Research Institute of Wuhan University of Technology, Shenzhen, 518000, China. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, China.

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The effect of silicon groups on the physicochemical property and bioactivity of L-phenylalanine derived poly(amide-imide)

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