资源类型：
期刊
WOS体系：
Article
Pubmed体系：
Journal Article
收录情况：
◇ SCIE
文章类型：
论著
单位：
[1]Departments of Neurosurgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province 510630, China.
中山大学附属第三医院
[2]Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
药学部
华中科技大学同济医学院附属同济医院
ISSN：
2589-0042
摘要：
Deficits in astrocyte function contribute to major depressive disorder (MDD) and suicide, but the therapeutic effect of directly reactivating astrocytes for depression remains unclear. Here, specific gains and losses of astrocytic cell functions in the medial prefrontal cortex (mPFC) bidirectionally regulate depression-like symptoms. Remarkably, recombinant human Thrombospondin-1 (rhTSP1), an astrocyte-secreted protein, exerted rapidly antidepressant-like actions through tyrosine hydroxylase (Th)/dopamine (DA)/dopamine D2 receptors (D2Rs) pathways, but not dopamine D1 receptors (D1Rs), which was dependent on SH3 and multiple ankyrin repeat domains 3 (Shank3) in the mPFC. TSP1 in the mPFC might have potential as a target for treating clinical depression.© 2023 The Author(s).
基金：
This work was supported by the Science and Technology Program of Guangzhou, China under Grant No.
201604020080 to YG; the Guangdong Basic and Applied Basic Research Foundation under Grant
No. 2018B0303110014 to YG; the National Natural Scientific Foundation of China (NSFC) under Grant
No. 81901211 to CC, No. 82003730 to SQG and No. 82003736 to HYZ.
被引次数：
1
WOS：
WOS:000996411600001
PubmedID：
37091229
中科院(CAS)分区：
出版当年[2022]版：
大类
|
2 区
综合性期刊
小类
|
2 区
综合性期刊
最新[2025]版：
大类
|
2 区
综合性期刊
小类
|
2 区
综合性期刊
JCR分区：
出版当年[2021]版：
Q1
MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1
MULTIDISCIPLINARY SCIENCES
影响因子：
4.6
最新[2023版]
5
最新五年平均
6.107
出版当年[2021版]
6.233
出版当年五年平均
5.458
出版前一年[2020版]
5.8
出版后一年[2022版]
第一作者：
Gao Shuang-Qi
第一作者单位：
[1]Departments of Neurosurgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province 510630, China.
共同第一作者：
Chen Jun-Quan;Zhou Hai-Yun;Luo Lun
通讯作者：
Gao Shuang-Qi;Chen Chuan;Guo Ying
推荐引用方式(GB/T 7714)：
Gao Shuang-Qi,Chen Jun-Quan,Zhou Hai-Yun,et al.Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors[J].ISCIENCE.2023,26(4):doi:10.1016/j.isci.2023.106488.
APA：
Gao Shuang-Qi,Chen Jun-Quan,Zhou Hai-Yun,Luo Lun,Zhang Bao-Yu...&Guo Ying.(2023).Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors.ISCIENCE,26,(4)
MLA：
Gao Shuang-Qi,et al."Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors".ISCIENCE 26..4(2023)
