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Long intergenic non-protein coding RNA 00858 participates in the occurrence and development of esophageal squamous cell carcinoma through the activation of the FTO-m6A-MYC axis by recruiting ZNF184

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收录情况： ◇ SCIE

作者：
Ke Shun[1,2] * ; Wang Jing[3] ; Lu Jun[1,2] ; Fang Minghao[1,2] ; Li Ruichao[4,*1] ;
单位： [1]Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China [2]Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China [3]Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430071, PR China [4]Department of General Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
出处：
DOI： 10.1016/j.ygeno.2023.110593
ISSN：

关键词： Long intergenic non-protein coding RNA 00858 Esophageal squamous cell carcinoma ZNF184 FTO MYC m6A

摘要：
We aimed at probing impact of LINC00858 on esophageal squamous cell carcinoma (ESCC) progression via ZNF184-FTO-m6A-MYC axis.Expression of related genes (LINC00858, ZNF184, FTO, and MYC) was detected in ESCC tissues or cells and their relationships were assessed. After expression alterations in ESCC cells, cell proliferation, invasion, migration, and apoptosis were detected. Tumor formation in nude mice was conducted.LINC00858, ZNF184, FTO, and MYC were overexpressed in ESCC tissues and cells. LINC00858 enhanced ZNF184 expression to upregulate FTO, which augmented MYC expression. LINC00858 knockdown diminished ESCC cell proliferative, migratory, and invasive properties while elevating apoptosis, which was negated by FTO overexpression. FTO knockdown exerted similar functions of LINC00858 knockdown on ESCC cell movements, which was annulled by MYC upregulation. Silencing LINC00858 repressed tumor growth and related gene expression in nude mice.LINC00858 modulated MYC m6A modification via FTO by recruiting ZNF184, thus facilitating ESCC progression.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of China (No.82002621) and Natural Science Foundation of Hubei Province (No.2021CFB380)
语种：
外文
被引次数：
WOS：
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 生物学
小类 | 3 区 遗传学 3 区 生物工程与应用微生物
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生物工程与应用微生物 3 区 遗传学
JCR分区：
出版当年[2021]版：
Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 GENETICS & HEREDITY
最新[2023]版：
Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 GENETICS & HEREDITY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China [2]Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China
通讯作者：
通讯机构： [4]Department of General Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China [*1]Department of General Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Ave, Hankou District, Wuhan, Hubei 430030, PR China
推荐引用方式(GB/T 7714)：
Ke Shun,Wang Jing,Lu Jun,et al.Long intergenic non-protein coding RNA 00858 participates in the occurrence and development of esophageal squamous cell carcinoma through the activation of the FTO-m6A-MYC axis by recruiting ZNF184[J].GENOMICS.2023,115(3):doi:10.1016/j.ygeno.2023.110593.
APA：
Ke Shun,Wang Jing,Lu Jun,Fang Minghao&Li Ruichao.(2023).Long intergenic non-protein coding RNA 00858 participates in the occurrence and development of esophageal squamous cell carcinoma through the activation of the FTO-m6A-MYC axis by recruiting ZNF184.GENOMICS,115,(3)
MLA：
Ke Shun,et al."Long intergenic non-protein coding RNA 00858 participates in the occurrence and development of esophageal squamous cell carcinoma through the activation of the FTO-m6A-MYC axis by recruiting ZNF184".GENOMICS 115..3(2023)

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