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Olfactory Threshold Test as a Quick Screening Tool for Cognitive Impairment: Analysis of Two Independent Cohorts

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收录情况： ◇ SCIE

作者：
Gao Yang[1,2] * ; Liu Yanchao[3] ; Zhang Yao[4] ; Wang Yuying[1] ; Zheng Jie[5] ; Xu Zhipeng[6] ; Yu Haitao[1] ; Jin Zetao[1] ; Yin Yin[1] ; He Benrong[1] ; Sun Fei[1] ; Xiong Rui[1] ; Lei Huiyang[1] ; Jiang Tao[1] ; Liang Yi[2] ; Ke Dan[1] ; Zhao Shi[7] ; Mo Wen[8] ; Li Yanni[8] ; Zhou Qiuzhi[1] ; Wang Xin[1] ; Zheng Chenghong[9] ; Zhang Huaqiu[3] ; Liu Gongping[1] ; Yang Ying[1] ; Wang Jian-Zhi[1,10,*1] ;
单位： [1]Department of Pathophysiology, School of Basic Medicine, Ministry of Education Key Laboratory for Neurological Disorders, Hubei Key Laboratory for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Department of Radiology, Wuhan Brain Hospital, Wuhan, China. [3]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [4]Li-Yuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [5]Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University ,Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Peking University, Beijing, China. [6]Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China. [7]Department of Endocrinology, the Central Hospital of Wuhan, Wuhan, China. [8]Health Service Center of Jianghan District, Wuhan, China. [9]Department of Endocrinology, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, China. [10]Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.
出处：
DOI： 10.3233/JAD-230023
ISSN：

关键词： Cut-off value dementia mild cognitive impairment olfactory function type 2 diabetes mellitus

摘要：
Olfactory dysfunction appears prior to cognitive decline, and thus it has been suggested to be an early predictor of Alzheimer's disease. However, it is currently not known whether and how olfactory threshold test could serve as a quick screening tool for cognitive impairment.To define olfactory threshold test for screening cognitive impairment in two independent cohorts.The participants are comprised of two cohorts in China, 1,139 inpatients with type 2 diabetes mellitus (T2DM, Discovery cohort) and 1,236 community-dwelling elderly (Validation cohort). Olfactory and cognitive functions were evaluated by Connecticut Chemosensory Clinical Research Center test and Mini-Mental State Examination (MMSE), respectively. Regression analyses and receiver operating characteristic (ROC) analyses were carried out to determine the relation and discriminative performance of the olfactory threshold score (OTS) regarding identification of cognition impairment.Regression analysis showed that olfactory deficit (reducing OTS) was correlated with cognitive impairment (reducing MMSE score) in two cohorts. ROC analysis revealed that the OTS could distinguish cognitive impairment from cognitively normal individuals, with mean area under the curve values of 0.71 (0.67, 0.74) and 0.63 (0.60, 0.66), respectively, but it failed to discriminate dementia from mild cognitive impairment. The cut-off point of 3 showed the highest validity for the screening, with the diagnostic accuracy of 73.3% and 69.5%.Reducing OTS is associated with cognitive impairment in T2DM patients and the community-dwelling elderly. Therefore, olfactory threshold test may be used as a readily accessible screening tool for cognitive impairment.

基金：
This study was supported in parts by the Nat- 408 ural Science Foundation of China (91949205, 409 31730035, 81721005), the National Key R&D 410 Program of China (2016YFC1305800), the Funda- 411 mental Research Funds for the Central Universities 412 (YCJJ202203019), the Hubei Province scientific 413 research project (WJ2021M041), the Wuhan Health 414 Science Foundation (WX20Q04), the Guangdong 415 Provincial Key S&T Program (018B030336001). 416 The funders neither played a role in the study design, 417 conduct, data collection, analysis, interpretation, nor 418 participated in the preparation, review, approval of 419 the manuscript
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 3 区 神经科学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 神经科学
JCR分区：
出版当年[2021]版：
Q2 NEUROSCIENCES
最新[2024]版：
Q2 NEUROSCIENCES

影响因子： 最新[2024版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Department of Pathophysiology, School of Basic Medicine, Ministry of Education Key Laboratory for Neurological Disorders, Hubei Key Laboratory for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Department of Radiology, Wuhan Brain Hospital, Wuhan, China.
通讯作者：
通讯机构： [1]Department of Pathophysiology, School of Basic Medicine, Ministry of Education Key Laboratory for Neurological Disorders, Hubei Key Laboratory for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [10]Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China. [*1]Department of Pathophysiology, School of Basic Medicine, Ministry of Education Key Laboratory for Neurological Disorders, Hubei Key Laboratory for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
推荐引用方式(GB/T 7714)：
Gao Yang,Liu Yanchao,Zhang Yao,et al.Olfactory Threshold Test as a Quick Screening Tool for Cognitive Impairment: Analysis of Two Independent Cohorts[J].JOURNAL OF ALZHEIMERS DISEASE.2023,93(1):169-178.doi:10.3233/JAD-230023.
APA：
Gao Yang,Liu Yanchao,Zhang Yao,Wang Yuying,Zheng Jie...&Wang Jian-Zhi.(2023).Olfactory Threshold Test as a Quick Screening Tool for Cognitive Impairment: Analysis of Two Independent Cohorts.JOURNAL OF ALZHEIMERS DISEASE,93,(1)
MLA：
Gao Yang,et al."Olfactory Threshold Test as a Quick Screening Tool for Cognitive Impairment: Analysis of Two Independent Cohorts".JOURNAL OF ALZHEIMERS DISEASE 93..1(2023):169-178

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