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International Consensus Guideline on Small for Gestational Age (SGA): Etiology and Management from Infancy to Early Adulthood

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收录情况： ◇ SCIE

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单位： [1]Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands [2]Department of Pediatrics, Federal University of Parana, 1154 Curitiba, Brazil [3]Department of Systems Medicine, University of Rome ‘Tor Vergata’, 00133 Rome, Italy [4]Diabetology and Growth Disorders Unit, IRCCS “Bambino Gesù ” Children’s Hospital, 00146 Rome, Italy [5]Department of Women’s and Children’s Health, Karolinska Institute, 17177 Stockholm, Sweden [6]Department of Pediatrics, The Sahlgrenska Academy, the University of Gothenburg and Queen Silvia Children’s Hospital, 41650 Gothenburg, Sweden [7]Division of Endocrinology and Metabolism, National Center for Child Health and Development, 578535 Tokyo, Japan [8]Institute of Maternal and Child Research, Faculty of Medicine, University of Chile, 8320000 Santiago de Chili, Chili [9]Icahn School of Medicine, Division of Pediatric Endocrinology, Mount Sinai Kravis Children’s Hospital, New York, NY 10029, USA [10]Medical Division, Al Habib Medical Group, Riyadh 12214, Saudi Arabia [11]Centro de Investigaciones Endocrinológicas “Dr. Cesar Bergadá” (CEDIE), División de Endocrinología, Hospital de Niños Dr. Ricardo Gutiérrez, C1425 Buenos Aires, Argentina [12]Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, 11527 Athens, Greece [13]Division of Endocrinology and Metabolism, Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece [14]Department of Pediatrics, Section of Diabetes and Endocrinology, University of Oklahoma Health Sciences Center, OK 73104 Oklahoma City, USA [15]Division of Pediatric Endocrinology, Liggins Institute, University of Auckland, Auckland 1142, New Zealand [16]Division of Endocrinology, Children’s National Hospital, Washington, DC 20012, USA [17]Paediatric Endocrine Division, Sheikh Shakhbout Medical City and College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates [18]Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA [19]Unidade de Endocrinologia Genética (LIM25) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil [20]Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan [21]Department of Pediatrics, Jehangir Hospital, Pune, India [22]Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China [23]Department of Pediatrics, Christian Medical College, Vellore, India [24]Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan

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关键词： SGA etiology consequences management genetics GH

摘要：

This International Consensus Guideline was developed by experts in the field of SGA of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Besides, it presents long-term consequences of SGA birth and new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, and the metabolic and cardiovascular health of young adults born SGA after cessation of childhood-GH-treatment in comparison with appropriate control groups. To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardio-metabolic health profile in adulthood. Children born SGA with persistent short stature < -2.5 SDS at age 2 years or < -2 SDS at age of 3-4 years, should be referred for diagnostic work-up. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033-0.067 mg GH/kg/day is recommended in case of persistent short stature at age of 3-4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.© The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.

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出版当年[2022]版中科院分区表Review为是的期刊

：

大类 | 1 区

医学

小类 | 1 区内分泌学与代谢

最新[2025]版

：

大类 | 1 区

医学

小类 | 1 区内分泌学与代谢

JCR分区：

出版当年[2021]版：

Q1 ENDOCRINOLOGY & METABOLISM

最新[2023]版：

Q1 ENDOCRINOLOGY & METABOLISM

影响因子： 22 最新[2023版] 26.5 最新五年平均 25.261 出版当年[2021版] 27.899 出版当年五年平均 19.871 出版前一年[2020版] 20.3 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands [*1]Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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通讯作者：

通讯机构： [1]Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands [*1]Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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International Consensus Guideline on Small for Gestational Age (SGA): Etiology and Management from Infancy to Early Adulthood