The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function as E3 ligases to facilitate specific proteasomal degradation of target proteins. In addition, E3 ligase independent functions of TRIM protein were also reported. In hepatocellular carcinoma, expressions of TRIM proteins are both regulated by genetic and epigenetic mechanisms. TRIM proteins regulate multiple biological activities and signaling cascades. And TRIM proteins influence hallmarks of HCC. This review systematically demonstrates the versatile roles of TRIM proteins in HCC and helps us better understand the molecular mechanism of the development and progression of HCC.
基金：
National Nature Science Foundation of China [81874065, 81874149]; National Basic Research Program of China [2020YFA0710700]; Tongji Hospital (HUST) Fundation for Excellent Young Scientist [2020YQ05]; first level of the public health youth top talent project of Hubei province
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan 430030, Hubei, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hubei Key Lab Hepatopancreatobiliary Dis, Wuhan 430030, Hubei, Peoples R China[3]Clin Med Res Ctr Hepat Surg Hubei Prov, Wuhan, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Lu Kan,Pan Yonglong,Huang Zhao,et al.TRIM proteins in hepatocellular carcinoma[J].JOURNAL OF BIOMEDICAL SCIENCE.2022,29(1):doi:10.1186/s12929-022-00854-7.
APA：
Lu, Kan,Pan, Yonglong,Huang, Zhao,Liang, Huifang,Ding, Ze-Yang&Zhang, Bixiang.(2022).TRIM proteins in hepatocellular carcinoma.JOURNAL OF BIOMEDICAL SCIENCE,29,(1)
MLA：
Lu, Kan,et al."TRIM proteins in hepatocellular carcinoma".JOURNAL OF BIOMEDICAL SCIENCE 29..1(2022)
医学