Ectopic adrenocorticotropic hormone (ACTH) syndrome caused by paraganglioma is extremely rare. It usually accompanied by high or normal plasma ACTH level. Here we described a male who presented with ectopic ACTH-producing paraganglioma and a low plasma ACTH level. Immunohistochemistry and immunofluorescence confirmed ACTH production in focal paraganglioma cells. This unusual case expanded the spectrum of ACTH-dependent Cushing's syndrome and revealed a potential mechanism of this unique clinical phenotype. Besides, the literature concerning ACTH-producing paraganglioma is reviewed.
基金：
National Natural Science Foundation of China (NSFC) [81770817]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Endocrinol, Wuhan, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Liu Siyue,Liu Zhelong,Chen Fuqiong,et al.Adrenocorticotropic Hormone-Producing Paraganglioma With Low Plasma ACTH Level: A Case Report and Review of the Literature[J].FRONTIERS IN ENDOCRINOLOGY.2020,10:doi:10.3389/fendo.2019.00936.
APA：
Liu, Siyue,Liu, Zhelong,Chen, Fuqiong,Xu, Weijie&Yuan, Gang.(2020).Adrenocorticotropic Hormone-Producing Paraganglioma With Low Plasma ACTH Level: A Case Report and Review of the Literature.FRONTIERS IN ENDOCRINOLOGY,10,
MLA：
Liu, Siyue,et al."Adrenocorticotropic Hormone-Producing Paraganglioma With Low Plasma ACTH Level: A Case Report and Review of the Literature".FRONTIERS IN ENDOCRINOLOGY 10.(2020)
